_Promissary Notes on the Treasury of Merits_ offers an important selection of work on a neglected topic of medieval European religious history. The contributions clearly demonstrate the vibrant, multi-faceted, and at times contested, role which indulgences played in many aspects of medieval catholic life.

Reprint of the original, first published in 1919.

The Individual and the Political Order examines major theoretical perspectives, both historical and contemporary, in major issues in social and political philosophy. It combines accessibility with appreciation of philosophical complexity and discusses applied issues, such as morality and war, as well as theoretical approaches to justice, rights, and democratic liberal thought.

This collection of essays is addressed to the legacy of Enlightenment thought, with respect to eighteenth-century notions of human nature, human rights, representative democracy or the nation-state, and with regard to the barbarism, including the Holocaust, allegedly unleashed by eighteenth-century ideals of civilization. Each author offers an interpretation of modern or postmodern philosophy against the background of a so-called Enlightenment Project, envisaged as the conceptual ghost that haunts modernity.

Though hippocampal volume reduction is a pathological hallmark of schizophrenia, the molecular pathway responsible for this degeneration remains unknown. Recent reports have suggested the potential role of impaired blood-brain barrier function in schizophrenia pathogenesis. However, direct evidence demonstrating an impaired BBB function is missing. In this preliminary study, we used immunohistochemistry and serum immunoglobulin G antibodies to investigate the state of BBB function in formalin-fixed postmortem samples from the hippocampus and surrounding temporal cortex of patients with schizophrenia and controls without (...) schizophrenia matched for age, sex, and race. Since a functional BBB prevents the extravasation of IgGs, detection of IgGs in the parenchyma is used as direct evidence of BBB breakdown. We also developed a semi-quantitative approach to quantify the extent of IgG leak and therein BBB breach. Analysis of our immunohistochemistry data demonstrated a significantly higher incidence of IgG leak in patients with schizophrenia compared to controls. Further, BBB permeability was significantly higher in advanced-age patients with schizophrenia than both advanced-age controls and middle-aged patients with schizophrenia. Male patients with schizophrenia also demonstrated a significant increase in IgG permeability compared to control males. Interestingly, the extravasated IgGs also demonstrated selective immunoreactivity for neurons. Based on these observations, we suggest that BBB dysfunction and IgG autoantibodies could be two key missing pathoetiological links underwriting schizophrenia hippocampal damage. (shrink)

In 1945, Michael Polanyi achieved, in Full Employment and Free Trade, the integration of Keynesian and monetarist economics that the economics profession did not ahieve until the 1970s. In yet another field, Polanyi saw the heart of important matters long before anyone else.

THE nature of the self and of self knowledge is a problem that has not ceased to intrigue and perplex philosophers since the day that Socrates made his own the Delphic precept ‘Know Thyself’. It has been of particular interest to philosophers, however, since Descartes took the Cogito as the basis of his philosophy. In modern times we have only to think of Hume’s vain search for the self, of Kant’s transcendental apperception, and of Fichte’s Ego. And in contemporary times (...) we have before us the descriptions that Husserl and Sartre have given of the constitution of the ego, and the enigmatic remarks that Wittgenstein makes in his Tractatus about the subject being the limit of the world. (shrink)

We show that, in terms of both implication and consistency strength, an extendible with a larger strong cardinal is stronger than an enhanced supercompact, which is itself stronger than a hypercompact, which is itself weaker than an extendible. All of these are easily seen to be stronger than a supercompact. We also study Cn‐supercompactness.

Rather than starting with traits and speculating whether selective forces drove evolution in past environments, we propose starting with a candidate gene associated with a trait and testing first for patterns of selection at the DNA level. This can provide limitations on the number of traits to be evaluated subsequently by adaptationism as described by Andrews et al.

This chapter contains sections titled: Belonging and genealogical bonds Beholdenness and reciprocal relations Respect, or the wish‐to‐be‐appreciated Knowledge, inherent value, and landkeeping.

In this unique volume, some of today's most eminent political philosophers examine the thought of John Rawls, focusing in particular on his most recent work. These original essays explore diverse issues, including the problem of pluralism, the relationship between constitutive commitment and liberal institutions, just treatment of dissident minorities, the constitutional implications of liberalism, international relations, and the structure of international law. The first comprehensive study of Rawls's recent work, The Idea of Political Liberalism will be indispensable for political philosophers (...) and theorists interested in contemporary political thought. (shrink)

Evidence suggests that one reason doctors provide certain interventions in assisted reproductive technologies (ART) is because of patient demand. This is particularly the case when it comes to unproven interventions such as ‘add‐ons’ to in vitro fertilisation (IVF) cycles, or providing IVF cycles that are highly unlikely to succeed. Doctors tend to accede to demands for such interventions because patients are willing to do and pay ‘whatever it takes’ to have a baby. However, there is uncertainty as to what moral (...) weight should be placed on patient‐led demands in ART, including whether it is acceptable for such demands to be invoked as a justification for intervention. We address this issue in this paper. We start by elucidating what we mean by ‘patient‐led demand’ and synthesise some of the evidence for this phenomenon. We then argue that a doctor's professional role morality (PRM) yields special responsibilities, particularly in commercialised healthcare settings such as ART, because of the nature of professions as social institutions that are distinct from markets. We argue on this basis that, while there may be reasons (consistent with PRM) for doctors to accede to patient demand, this is not always the case. There is often a gap in justification between acceding to patient‐led demands and providing contested interventions, particularly in commercial settings. As a result, acceding to demand in such settings needs a strong justification to be consistent with PRM. (shrink)

Recovering Reason: Essays in Honor of Thomas L. Pangle is a collection of essays composed by students and friends of Thomas L. Pangle to honor his seminal work and outstanding guidance in the study of political philosophy. These essays examine both Socrates' and modern political philosophers' attempts to answer the question of the right life for human beings, as those attempts are introduced and elaborated in the work of thinkers from Homer and Thucydides to Nietzsche and Charles Taylor.